Limited-time Discount: $49.9 Per Year
Limited-time offer: just $49.9! Early buyers enjoy full equal access to all iterative data updates for one year.
Vertical Industries Small Nucleic Acid Drugs

Small Nucleic Acid Drugs

01
Surging Heat in China's Sector

In 2026, momentum in China’s small nucleic acid drug sector keeps climbing. As a representative class of nucleic acid therapeutics, small nucleic acid drugs boast enormous development potential. Compared with conventional protein-targeted medicines, they feature high specificity, potent efficacy and durable therapeutic effects.

02
Specialized Survey of Nearly 100 Enterprises

VCBeat conducted a specialized survey of nearly 100 domestic relevant enterprises. It screened companies based on multiple dimensions including financing strength, product pipelines under development, cross-border partnerships and core teams. Furthermore, it categorized five segmented tracks by drug mechanisms of action and compiled a comprehensive industrial map for small nucleic acid drugs.

03

Multi-dimensional SNA Drug Industry Map

This map clearly presents the number of enterprises and core technological focuses across the five key segmented tracks. It also compiles basic profiles of nearly 100 companies, covering founding date, business location, staff size, contact information, official websites, financing history and corporate updates.

04
Full-spectrum Data Support & Collaboration

VCBeat has built in-depth connections with all enterprises on the map, offering exclusive cooperation channels and providing full-spectrum, authoritative data to support industrial planning, trend analysis, business collaboration and investment decision-making.

Industry Map

siRNA (70)
More
miRNA (5)
More
saRNA (1)
More
ASO (10)
More
Aptamer (2)
More

Finance

VIEW ALL
Time
Company Name
Brief Introduction
Area
Funding rounds
Amount
August 31, 2026
Nucleic Acid Drug Developer
Sichuan,China
Series A+
Undisclosed
August 27, 2026
Biological Vaccine and Nucleic Acid Drug Developer
Zhejiang,China
Series C
USD 120M
August 20, 2026
Innovative siRNA Drug Developer
Jiangsu,China
Series PreA
Undisclosed
August 20, 2026
Innovative siRNA Drug Developer
Jiangsu,China
Series A
Undisclosed
Time
Company Name
Brief Introduction
Area
Funding rounds
Amount
January 09, 2026
Small Nucleic Acid Drug Developer
Jiangsu,China
IPO
HKD 1.7018B
October 27, 2025
Innovative Drug Developer
Guangdong,China
IPO
CNY 1.491B
August 07, 2025
Innovative Drug Developer
Guangdong,China
IPO
Undisclosed
July 15, 2025
Professional Drug Developer
Guangdong,China
IPO
Undisclosed
June 30, 2022
Pharmaceutical Formulation and Medical Device R&D Developer
Beijing,China
IPO
CNY 1.636B
December 30, 2021
Nucleic Acid Interference New Drug Developer
Jiangsu,China
IPO
HKD 396M
July 13, 2021
Innovative Drug Research and Development Service Provider
Shanghai,China
IPO
HKD 2.3338B
May 20, 2021
Developer, Manufacturer, and Distributor of Peptides and Small-Molecule Chemical Drugs
Jiangsu,China
IPO
CNY 830M
February 08, 2021
Liver Disease Drug Manufacturer
Beijing,China
IPO
CNY 805.9M
December 24, 2020
Innovative Drug Research and Development, Production and Sales
Beijing,China
IPO
CNY 2.018B

Business Development

VIEW ALL
Transaction Type
Transaction Date
Transferor (Seller)
Transferee (Buyer)
Trading products
Clinical Stage
Amount
Source
license out
2026-09-03
QL2107
Phase III Clinical Trial
Undisclosed
domestic transactions
2026-09-02
Fully Human Nanobody Molecules
Preclinical Studies
Undisclosed
license in
2026-08-09
VANFLYTA®
NMPA Approval for Market Launch
Undisclosed
domestic transactions
2026-07-21
TY-9591
--
CNY 2.76B
license out
2026-07-14
IBI355
Phase II Clinical Trial in Preparation
USD 1.1B
domestic transactions
2026-07-13
Central Nervous System (CNS) Therapeutics
--
Undisclosed
cooperative development
2026-07-02
siRNA Candidate Drugs for Kidney Disease
Preclinical Studies
USD 1.77B
domestic transactions
2026-06-30
JS005
NMPA Marketing Application in Progress
CNY 1.34B
license in
2026-06-30
Verzenio®
NMPA Approval for Market Launch
Undisclosed
domestic transactions
2026-06-24
In Vivo CAR Therapy
--
Undisclosed

Industry Insights

VIEW ALL
Innovation
Novel RIPTAC Protein Degradation Technology Enters Global Clinical Trials, Led by Hengrui Pharma in China
The novel protein degradation technology RIPTAC (Regulated Induced Proximity TArgeting Chimeras) is advancing into global clinical trials, with Jiangsu Hengrui Pharmaceuticals emerging as a key leader in China. Hengrui's AR-directed RIPTAC candidate, HRS-7525, has initiated a global trial for metastatic castration-resistant prostate cancer (mCRPC), enrolling its first patient in July 2026. Operating via a unique 'Hold and Kill' mechanism, RIPTAC forms stable ternary complexes to selectively destroy cancer cells while sparing normal tissue, offering a precision approach with potentially fewer side effects. The technology's promise is underscored by Johnson & Johnson's $3.05 billion acquisition of RIPTAC pioneer Halda Therapeutics in 2025. With multiple Chinese pharmaceutical companies actively pursuing RIPTAC development, China is rapidly positioning itself as a major global player in this next-generation oncology therapeutic modality.
2min read
Read More
Innovation
Three Chinese Innovative NSCLC Drugs Granted Breakthrough Therapy Designation on Same Day
On September 7, China's Center for Drug Evaluation (CDE) proposed including three domestic innovative drugs in the breakthrough therapy program, all targeting non-small cell lung cancer (NSCLC). AnRun Medical Technology's AMX3009, an irreversible EGFR/HER2 inhibitor, is designated for first-line treatment of NSCLC with EGFR uncommon mutations. CSPC Pharmaceutical Group's SYS6010, an EGFR-targeting antibody-drug conjugate (ADC), is intended for relapsed or metastatic driver gene-negative non-squamous NSCLC. Multitude Therapeutics' AMT-116, a CD44v9-targeting ADC, is designed for EGFR wild-type non-squamous NSCLC patients who failed prior immunotherapy and chemotherapy. The simultaneous designations are expected to reshape NSCLC treatment in China and expand precision oncology options.
2min read
Read More
IPO
Shenzhen Salubris Pharmaceuticals Files for A+H Listing After Distributing RMB 7.8 Billion in Dividends
In September 2026, Shenzhen Salubris Pharmaceuticals applied for a Hong Kong listing, seeking an A+H structure after 17 years on the Shenzhen Stock Exchange. Since its 2009 A-share IPO, it has paid over RMB 7.8 billion in dividends, more than twice its fundraising. Under Chairman Ye Yuxiang, Salubris has shifted from generics to innovative biopharma focused on cardiorenal-metabolic (CKM) diseases. It now markets six innovative drugs and has built five proprietary platforms covering small molecules, antibodies, siRNA, cyclic peptides, and gene editing. Its pipeline includes 79 innovative drug candidates and 17 medical devices, led by the Maurora vertebral artery drug-eluting stent. Innovative drugs contributed 49% of H1 2026 revenue. Despite strong cash flow and growing innovation-driven revenue, Salubris is seeking a Hong Kong listing for a more favorable valuation amid perceived investor mispricing in mainland markets.
7min read
Read More
Business Development
Biocytogen Grants Qilu Pharmaceutical Non-Exclusive License for Fully Human Nanobody Molecule to Support Neuroscience Drug Development
Biocytogen Pharmaceuticals has signed a non-exclusive license agreement with Qilu Pharmaceutical, granting rights to a single fully human nanobody molecule generated via its proprietary RenNano® platform for use in neuroscience drug development. The deal includes an upfront payment and additional milestone-based payments tied to development, regulatory, and commercialization achievements. Qilu Pharmaceutical will integrate the molecule into its R&D pipeline to explore innovative treatments for nervous system diseases, leveraging Biocytogen's nanobody technology to address the high scientific and translational challenges in neuroscience drug R&D.
3min read
Read More
Innovation
Akeso's Ivonescimab Beats Keytruda in Overall Survival: Establishing the IO 2.0 Cornerstone and Triggering a Revaluation of Chinese Innovative Drugs
The interim analysis of the HARMONi-2 trial revealed that Akeso's ivonescimab demonstrated superior overall survival compared to pembrolizumab (Keytruda) in first-line PD-L1-positive non-small cell lung cancer. By outperforming the world's top-selling cancer therapy on the most rigorous clinical endpoint, ivonescimab cements the cornerstone status of IO 2.0 bispecific antibodies, transitioning the narrative from 'me-too' substitution to undeniable superiority. This landmark clinical victory has catalyzed a rally in the biotech sector and marks a pivotal shift from theme-based trading to data-driven valuation, prompting investors to fundamentally reassess and upgrade the clinical and commercial value of Chinese innovative drugs on the global stage.
3min read
Read More
Innovation
Huadong Medicine's Oral GLP-1 HDM1002 Achieves Phase III Primary Endpoint, NDA Filing Planned for Q4 2026
Huadong Medicine announced that its oral small-molecule GLP-1 receptor agonist HDM1002 (conveglipron) has met the primary endpoint in its Phase III trial for weight management in China, with a New Drug Application (NDA) planned for Q4 2026. Alongside parallel development for type 2 diabetes, the company is expanding its comprehensive metabolic pipeline, including the dual-target agonist HDM1005. This milestone marks a significant step in China's rapidly evolving oral weight-loss market, intensifying the competition in commercialization and multi-dimensional clinical value.
3min read
Read More
InnovationMNC China Lens
Hansoh Pharma Submits Marketing Application in China for B7-H3 ADC Risvutatug Rezetecan in Platinum-Refractory Small Cell Lung Cancer
Hansoh Pharmaceutical Group has submitted a China marketing application for risvutatug rezetecan (HS-20093), a fully human B7-H3 ADC with a topoisomerase inhibitor payload, for platinum-refractory small cell lung cancer (SCLC). The filing is supported by positive Phase III ARTEMIS-008 results announced in July 2026, which met its primary overall survival endpoint and significantly improved survival versus topotecan, with consistent progression-free survival benefits. Safety remained consistent with prior studies. This is the first positive Phase III result showing a B7-H3 ADC can significantly improve overall survival. In December 2023, Hansoh granted GSK exclusive rights to develop and commercialize the drug outside Greater China, where GSK is conducting Phase III trials. As SCLC accounts for about 15% of lung cancers and has limited second-line options, HS-20093 could address a significant unmet medical need.
1min read
Read More
Innovation
Legend Healthcare Portfolio Update | Issue 8, 2026
This issue highlights significant milestones for Legend Capital's healthcare portfolio companies. Harbour BioMed, Ribo Life Science, and Star Sports Medicine were included in the Hang Seng Composite Index, gaining Stock Connect eligibility. Key clinical and regulatory advancements include Innovent Biologics advancing its bispecific antibody into a third pivotal trial, Yilian Biopharm and lncTAC Biotech achieving approvals for novel ADCs and nucleic acid drugs, and Core Medical's artificial heart receiving EU MDR CE certification. Additionally, GenePlus Technology secured the world's first mNGS kit approval, and BioMap partnered with Legend-incubated Biogend on an AI-driven drug discovery NewCo. The update also covers breakthroughs in multi-ion therapy devices, Alzheimer's diagnostics, and strategic partnerships, alongside recognitions such as 19 portfolio companies being named to the 'GEI China Potential Unicorn Enterprises 2025' list.
7min read
Read More
Innovation
CSPC Pharmaceutical Unveils Positive Phase II Results of Novel PCSK9-Targeting siRNA SYH2053 at 2026 ESC Congress
At the 2026 ESC Congress in Munich, CSPC Pharmaceutical Group presented positive Phase II results for SYH2053, a novel PCSK9-targeting siRNA therapy for primary hypercholesterolemia and mixed dyslipidemia. The randomized, double-blind, controlled trial enrolled 156 Chinese patients across five groups. At Day 180, SYH2053 reduced placebo-adjusted LDL-C by 46.6%, 52.9%, and 46.4% at 150, 300, and 600 mg, respectively (all p<0.0001), with rapid and sustained reductions in LDL-C and PCSK9. The 300 mg group showed numerically greater LDL-C and PCSK9 reductions than 300 mg inclisiran with background therapy. SYH2053 had a favorable safety profile, with lower rates of liver enzyme elevation than inclisiran. Three Phase III trials are underway to further validate its efficacy and safety.
4min read
Read More
Innovation
Ribo Life Science Announces Phase 1 Clinical Results for Lipid-Lowering siRNA Drug RBD5044 at ESC 2026
Suzhou Ribo Life Science Co., Ltd. presented promising Phase 1 clinical data for RBD5044, an siRNA therapeutic targeting ApoC3, at the ESC Congress 2026. A single dose of RBD5044 suppressed ApoC3 levels by up to 84% and reduced triglycerides by up to 70%, with durable effects sustained over six months. The drug demonstrated good safety and tolerability with no liver enzyme elevations. RBD5044 is currently advancing into Phase 2 clinical trials in China and Sweden for the treatment of hypertriglyceridemia.
2min read
Read More

Unlock to access premium whole insights

More Details
Research-led
Multiple Dimensions
Updated Quarterly
High-quality Chinese Assets Selected